Publications

In Press

Thome, C., Mitz, C., Somers, C.M., Manzon, R.G., Boreham, D.R., Wilson, J.Y.. Incubation of Lake Whitefish (Coregonus clupeaformis) embryos in cooling water discharge and the impacts of fluctuating thermal regimes on development. Accepted to Canadian Journal of Fisheries and Aquatic Sciences.

Eberts, R.L., Wissel, B., Manzon, R.G., Wilson, J.Y., Boreham, D.R., and Somers, C.M. Stable Isotopes reveal niche particitioning and multi-time sclae diet shifts in sympatric Lake (Coregonus clupeaformis) and Rounch Whitefish (Prosopium cylindraceum) in Lake Huron. Accepted to Canadian Journal of Fisheries and Aquatic Sciences.

Graham, C.F., Eberts, R.L., Morgan, T.D., Boreham, D.R., Lance, S., Manzon, R.G., Martino, J.A., Rogers, S.M., Wilson, J.Y.,  Somers, C.M. Fine-Scale Ecological and Genetic Population Structure of Two Whitefish (Coregoninae) Species in the Vicinity of Industrial Thermal Emissions.  Accepted to PLOSone.

2016

Stefanovic, D.I., Manzon, L.A., Boreham, D.R., Somers, C.M., Wilson, J.Y., Manzon, R.G. 2016. Thermal Stress and the Heat Shock Response in Embryonic and Young of the Year Juvenile Lake Whitefish. Comparative Biochemistry and Physiology A, 193:1-10.

2015

Graham, C., Glenn,T.C., McArthur, A., Boreham, D.R., Kieran, T., Lance, S. Manzon, R., Martino, J.A., Pierson, T.,Rogers, S.M., Wilson, J. and Somers, C.M. 2015. Impacts of degraded DNA on Restriction Enzyme Associated DNA Sequencing (RADSeq). Molecular Ecology Resources, 15:1304-1315.

Sreetharan, S., Thome, C., Mitz, C. Eme, J., Meuller, C, Hulley, E., Manzon, R.G., Somers, C.M., Boreham, D., and Wilson, J.Y. 2015. Embryonic development of lake whitefish (Coregonus clupeaformis): a staging series, analysis of growth and impacts of fixation. Journal of Fish Biology 87:539-558.

Mueller, C.A., Eme, J., Boreham, D., Manzon, R.G., Somers, C.M., and Wilson, J.Y. 2015. Embryonic Critical Windows: Changes in incubation temperature alter survival, hatchling phenotype, and cost of development in Lake whitefish (Coregonus clupeaformis) embryos. Journal of Comparative Physiology B, 185:315-331.

Eme, J., Mueller, C.A., Manzon, R., Somers, C.M., Boreham, D.R. and Wilson, J.Y. 2015.Critical windows in embryonic development: Shifting incubation temeraptures alter heart rate and oxygen consumption of Lake Whitefish (Coreogonus clupeaformis) embryos and hatchlings. Comparative Biochemstry and Phsyiology Part A Molecular and Integrative Physiology 179:71-80.

2014

Dejong, C. and Wilson, J.Y* 2014. The cytochrome P450 superfamily complement (CYPome) in the annelid Capitella telata. PlosONE, 9:e107728.

Shaya, L, Dejong, C, and Wilson, J.Y. 2014.Expression patterns of cytochrome P450 3B and 3C genes in model fish species. Comparative Biochemistry and Physiology Part C Toxicology and Pharmacology 165:115-125.

Mitz, C, Thome, C, Cybulski, ME, LaFramboise, L, Wilson, JY1 and Boreham, D1. 2014. Small-scale rearing of Lake Whitefish (Coreogoneus clupeaformis) embryos for experimental aquaculture. North American Journal of Aquaculture 76:179-184. 1 equal contributors

Galus, M, Rangaranjan, S., Lai, A., Shaya, L., Balshine,S. and Wilson, J.Y. 2014. Effects of chronic, parental pharmaceutical exposure on zebrafish (Danio rerio) offspring. Aquatic Toxicology, 151:124-134.

2013

Galus, M., Kirischian, N., Higgins, S., Purdy, J., Chow, J., Ragaranjan, S., Li, H., Metcalfe, C., and Wilson, J.Y. 2013. Chronic, low concentration exposure to pharmaceuticals impacts mulitple organ systems in zebrafish. Aquatic Toxicology,132-133:200-211 .

Galus, M., Jeyaranjaan, J., Smith, E.M., Li, H, Metcalfe, C., and Wilson, J.Y. 2013. Chronic Effects of Exposure to a Pharmaceutical Mixture and Municipal Wastewater in Zebrafish. Aquatic Toxicology, 132-133:212-222.

2012

Smith, E.S., Iftikar, F.I., Higgins, S., Irshad, S., Jandoc, R., Lee, M., and Wilson, J.Y. 2012. In vitro inhibition of cytorchrome P450-mediated reactions by gemfibrozil, erythromycin, ciprofloxacin and fluoxetine in fish liver microsomes. Aquatic Toxicology, 109:259-266.

2011

Harskamp, J., Britz-McKibbin, P.*, and Wilson, J.Y. 2011. Functional Screening of Cytochrome P450 Activity and Uncoupling by Capillary Electrophoresis. Analytical Chemistry, 84: 862–866.

Kirischian, N.L. and Wilson, J.Y. 2011. Phylogenetic and functional analyses of the cytochrome P450 family 4. Molecular Phylogenetics and Evolution, 62:458-471.

Kirischian, N., McArthur A.G., Jesuthasan C., Krattenmacher B., and Wilson J.Y. 2011. Phylogenetic and Functional Analysis of the Vertebrate Cytochrome P450 2 Family. Journal of Molecular Evolution, 72:56-71.

2010

Scornaienchi, M.L., Thornton, C., Willett, K.L., Wilson, J.Y.  2010. Cytochrome P450 mediated 17-beta estradiol metabolism in zebrafish (Danio rerio). Journal of Endocrinology, 206:317-325.

Marentette, J.R., Gooderham,K.L., Hynes, H., McMaster, M.E.,  Ng, T., Parrott, J.L., Slater, G.F., Wilson, J.Y., Wood, C.M., and Balshine, S. 2010. Signatures of Contamination in Invasive Round Gobies (Neogobius melanostomus): A double strike for ecosystem health in highly polluted areas? Journal of Ecotoxicology and Environmental Safety, 73:1755-1764.

Scornaienchi, M.L., Thornton, C., Willett, K.L., Wilson, J.Y.  2010. Functional differences in the cytochrome P450 1 family enzymes from Zebrafish (Danio rerio) using heterologously expressed proteins.  Archive of Biochemistry and Biophysics, 502:17-22.

Bowley, L.A., Alam, F., Marentette, J.R., Balshine, S., Wilson, J.Y. 2010. Characterization of vitellogenin gene expression in round goby (Neogobius melanostomus) using a quantitative PCR assay. Environmental Toxicology and Chemistry, 29:2751-2760.

Smith, E.M. and Wilson, J.Y. 2010. Assessment of cytochrome P450 fluorometric substrates with rainbow trout and killifish exposed to dexamethasone, pregnenolone-16α-carbonitrile, rifampicin, and β-naphthoflavone. Aquatic Toxicology 97:324-333.

Smith, E.M., Chu, S., Paterson, G., Metcalfe, C.D. and Wilson J.Y. 2010. Cross species comparison of fluoxetine metabolism with fish liver microsomes. Chemosphere 79:26-32.

Wilson, J.Y. and Stegeman J.J. 2010. Catalytic and Immunochemical Detection of Hepatic and Extrahepatic Microsomal Cytochrome P450 1A1 (CYP1A1) in White-sided Dolphin (Lagenorhynchus acutus) Aquatic Toxicology 96:216-224.

2009

Noori, A., Selvaganapathy, P.R., and Wilson, J. 2009. Microinjection in a microfluidic format using flexible and compliant channels and electroosmotic dosage control. Lab on a Chip 9: 3202:3211.

2008

Hooker, S.K., Metcalfe, T.L., Metcalfe, C.D., Angell, C.M., Wilson, J.Y., Moore, M.J., and Whitehead, H. 2008. Changes in persistent contaminant load and CYP1A1 enzyme activity in biopsy samples from Northern bottlenose whales, Hyperoodon ampullatus, following the onset of nearby oil and gas activity. Environmental Pollution, 152 (1): 205-216.

2007

Wilson, J.Y., Wells, R. Aguiliar, A., Borrell, A., Tornero, V., Reijnders, P., Moore, M., and Stegeman, J.J.  2007. Corrrelates of cytochrome P450 1A1(CYP1A1) expression in bottlenose dolphin (Tursiops truncatus) integument biopsies. Toxicological Sciences, 97(1):111-119.

2006

Garrick, R.A., Woodin, B.R., Wilson, J.Y., Middlebrooks, B.L., and Stegeman, J.J.  2006.  Cytochrome P4501A is induced in endothelial cell lines from the kidney and lung of the bottlenose dolphin, Tursiops truncatus. Aquatic Toxicology, 76(3-4):295-305.

2005

Wilson, J.Y., Cooke,S.R., Moore, M.J., Martineau, D., Mikaelian, I., Metner, D.A., Lockhart, W.L., and Stegeman, J.J. 2005.   Systemic Effects of Arctic Pollutants in Beluga whales Indicated by CYP1A1 expression.  Environmental Health Perspectives, 113(11):1594-1599.

Wilson, J.Y., McArthur, A.G., and Stegeman, J.J. 2005. Characterization of a Cetacean Aromatase (CYP19) and the Phylogeny and Functional Conservation of Vertebrate Aromatase.  General and Comparative Endocrinology, 140:74-83.

2004

Angell, C.M., Wilson, J.Y., Moore, M.J. and Stegeman, J.J. 2004 Cytochrome P450 1A1 expression in cetacean integument: implications for detecting contaminant exposure and effects.  Marine Mammal Science 20(3):554-566.

Godard, C., Smolowitz, R., Wilson, J.Y., Payne, R., Stegeman, J.J. 2004. Induction of cetacean cytochrome P4501A1 by B-naphthoflavone exposure of skin biopsy slices. Toxicological Sciences 80:268-275.

2001

Wilson, JY; Kruzynski, GM; Addison, RF. 2001. Experimental exposure of juvenile chinook (Oncorhynchus tshawytscha) to bleached kraft mill effluent: hepatic CYP1A induction is correlated with DNA adducts but not with organochlorine residues. Aquatic Toxicology, 53(1):49-63.

2000

Wilson, J.Y., Addison, R.F., Martens, D., Gordon, R. and Glickman, B. 2000. Cytochrome P450 1A and related measurements in juvenile chinook (Oncorhynchus tshawytscha) from the Fraser River.  Canadian Journal of Fisheries and Aquatic Sciences,  57(2):405-413.

1996

Hodson, P.V., Efler, S., Wilson, J.Y., El-Shaarawi, A., Maj, M. and Williams, T.G. 1996. Measuring the Potency of Pulp Mill Effluents for Induction of Hepatic Mixed Function Oxygenase Activity in Fish. Journal of Toxicology and Environmental Health, 49(1):83:110.

1993

LaPierre, N., Wilson, J., Bourreau, J.P., Tougas, G., Kwan, C.Y., Daniel, E.E. 1993. Norepinephrine Release in Rat Vas Deferens – Effect of Rauwolscine and BHT-920. Life Sciences, 53(2): PL19-PL24.

Recent Posts

Women of Distinction: 2018 Edition

That special time of year is almost upon us again, the chance to celebrate Hamilton’s Women of Distinction.  And like many years, the McMaster community is out in full force.  I’m not sure exactly what it is about our community that produces so many exceptional women but in many years McMaster women make up over half of all nominees and every single Young Woman of Distinction.  That is an achievement for which the McMaster community should be very, very proud.  I encourage you to read their biographies and hear their stories to find some great inspiration.  These women are smart, enthusiastic, energetic, exceptional and contribute to our community in so many unique ways.   For me, the best categories to read about are at the opposite end of the spectrum, the Life Time Achievement nominees and the Young Woman of Distinctions.  I am really not sure how anyone in either category can achieve so much.

2018 is a special year for our lab because Ushma Purohit is a nominee in the Young Woman of Distinction category.  Ushma has been a Wilson Tox Lab member since her 2nd year of university, when she asked me to supervise her in an experiential learning course.  She was keen to get into a lab and gain some hands on experience and excited to join a new area for our lab.  Ushma worked with another stellar undergraduate researcher, Abby Lee, to develop hydra as a model system to study the impacts of human pharmaceuticals on aquatic species.  Abby was completing her senior thesis, assessing the effects of chronic exposure of hydra to an anti-epileptic and an anti-depressant pharmaceutical.  Ushma learned how to prepare, stain, and count the different cell typess from hydra so we could identify whether there were changes in the proportions of cell types after exposure.  That research is now being written into a manuscript for publication.  I often point to this area of our research program to demonstrate how impactful undergraduate researchers can be.

Ushma has continued to volunteer and complete research course work in my lab and is now in her senior year.  She has gone from assisting others on research to running her own.  Her senior thesis research focuses on the anti-microbial compound triclosan and whether this impacts compound negatively impacts hydra biology.  She is a bright and independent researcher with a great future.  Yet, this is just the tip of the iceberg.  Beyond her classes and research, Ushma has been contributing to her communities at McMaster, in the larger city of Hamilton, and beyond.

So what does it take to be a Young Woman of Distinction?  Well let’s just list two of Ushma’s accomplishments outside of the lab.  Ushma founded the first Canadian chapter of the organization She’s the First, which champions education of girls in low-income countries.  The McMaster chapter has focused on raising funds and education campaigns including conferences, art showcases, recreational events, and awareness videos, to encourage the conversation around intersectional feminisim within the McMaster community. Within Hamilton, this club has hosted educational workshops at the local Native Women’s Centre on health, self-care and other topics and in Hamilton’s elementary schools to educate students on topics such as communication and the media, body image and bullying, and female leadership. Not so surprisingly, this club has won two awards within its first year; a McMaster Student Union award for the Best New Club of the Year and an award from the parent organization for Outstanding Achievement in Community Engagement.

Ushma is the current President of the UNICEF club at McMaster University, a club she has been active in for over 3 years.  It is one of the largest clubs on campus and raises funds to support the health and education of children and raise awareness of humanitarian issues within the McMaster community.  The McMaster UNICEF club sends over 100 volunteers to the Children’s International Learning Centre and supports education of young children through a variety of initiatives.

What has Ushma’s nomination meant to her?

“The experience of becoming a nominee for the Women of Distinction awards has been a lot more meaningful for me than I could have imagined. This nomination provided me with the opportunity to learn about and interact with some of the most driven, hard-working and talented women in Hamilton. As an individual who is currently at the advent of her career, experiences like this play a pivotal role in moulding my ambitions and aspirations for the future. Regardless of who wins the Young Woman of Distinction Award, I believe that as nominees, we have won an eye-opening experience that we will carry with us in the years to come.”

Feel inspired yet?  This isn’t a complete list of all she does, but just a couple of highlights of what this young woman of distinction has already accomplished.  Ushma is just one of 34 nominees for the 2018 YWCA Hamilton Women of Distinction awards.  Take a few minutes and read about who they are and what they do.  Regardless of who wins the awards, McMaster and Hamilton are the big winners here because these women are exceptional.

  1. Bring on the summer! Leave a reply
  2. Meet Devon Jones, undergraduate researcher Leave a reply
  3. Meet Abigail Lee, undergraduate researcher Leave a reply
  4. So, you want to be a session chair? Leave a reply