In Press

Choi, E., Alsop, D,and Wilson, J.Y. The effects of chronic acetaminophen exposure on the kidney, gill, and liver in rainbow trout (Oncorhynchus mykiss). Accepted to Aquatic Toxicology.


Morgan, T.D.; Graham, C.F.; McArthur, A.G.; Raphenya, A.R.; Boreham, D.R.; Manzon, R.G.;Wilson, J.Y.,Lance, S.L.; Howland, K.L.; Patrick, P.H.; Somers, C.M.  2018. Genetic population structure of the round whitefish (Prosopium cylindraceum) in North America: multiple markers reveal glacial refugia and regional subdivision. Canadian Journal of Fisheries and Aquatic Sciences, 75:836-849.

Fraz, S., Lee, A.H.,and Wilson J.Y. 2018. Gemfibrozil and carbamazepine decrease steroid production in zebrafish testes (Danio rerio). Aquatic Toxicology, 198:1-9.

Hammill, K.M., Fraz, S., Lee, A.H., and Wilson, J.Y. 2018. The effects of parental carbamazepine exposure on sexual differentiation in zebrafish (Danio rerio). Environmental Toxicology and Chemistry, 37:1696-1706.

Sreetharan, S., Thome, C., Tsang, K.K.;Somers, C.M.; Manzon, R.G.; Boreham, D.R.; Wilson, J.Y. 2018. Micronuclei formation in rainbow trout cells exposed to multiple stressors: morpholine, heat shock, and ionizing radiation. Toxicology In Vitro 47:38-47. 


Lim, M.Y.T., Manzon, R.G., Somers, C.M., Boreham, D.R., and Wilson, J.Y. 2017. The effects of fluctuating temperature regimes on the embryonic development of lake whitefish (Coregonus clupeaformis). Comparative Biochemistry and Physiology A Molecular and Integrative Physiology, 214:19-29.

Thome, C,Mitz, C, Manzon, R, Somers, C, Wilson, JY and Boreham, D. 2017 Initial Characterization of the growth stimulation and heat shock induced adaptive response in developing lake whitefish embryos after ionizing radiation. Radiation Research188:475-485.

Mitz, C,  Thome, C,Manzon, R, Somers, C, Wilson, JY and Boreham, D 2017 Is there a trade-off between radiation stimulated growth and metabolic efficiency? Radiation Research188:486-494.

Whitehouse, L.M., McDougall, C.S., Stefanovic, D.I., Boreham, D.R., Somers, C.M., Wilson J.Y., and Manzon, R.G. 2017. Development of the embryonic heat shock response and the impact of repeated thermal stress in early stage lake whitefish (Coregonus clupeaformis) embryos. Journal of Thermal Biology 69:294-301.

Mueller, C.A., Doyle, L., Eme, J.,Manzon, R.G, Somers, C.M,Boreham, D.R., and Wilson, J.Y. 2017. Lipid content and fatty acid profile during development of lake whitefish (Coregonus clupeaformis) embryos at different incubation temperatures. Comparative Biochemistry and Physiology A Molecular and Integrative Physiology 203:201-209.

Mitz, C, Thome, C,Thompson, J, Manzon, R, Somers, C, Wilson, JY1and Boreham, D2017. A method to transform a variable thermal regime to an equivalent constant temperature. Journal of Thermal Biology 65:21-25. 1equal contributors

Thome, C,Mitz, C,, Sreetharan, S., Mitz, C., Somers, C,  Manzon, R, Boreham, D., and Wilson, JY. 2017. Developmental effects of the industrial cooling water additives morpholine and sodium hypochlorite on lake whitefish  (Coregonus clupeaformis).Environmental Toxicology and Chemistry, 36:1955-1965.

Verbueken, E, Alsop, D.,Saad, M.A., Pype, C., Van Peer, E.M., Casteleyn, C.R., Van Ginneken, C.J, Wilson, J.Y.,and Van Cruchten, S.J. 2017 In Vitro Biotransformation of Two Human CYP3A Probe Substrates and its Inhibition during Early Zebrafish Development. International Journal of Molecular Sciences19: E217.

Sreetharan, S.; Thome, C.; Tharmalingam, S.; Jones, D.E.; Kulesza, A.Y.; Wilson, J.Y., Boreham, D.R.; Tai, T.C. 2017 Ionizing Radiation Exposure During Pregnancy: Effects on Postnatal Development and Life. Radiation Research187:647-658.

Eberts, R.L., Wissel, B., Simpson, G.L., Crawford, S.S., Stott, W., Hanner, R.H., Manzon, R.G., Wilson, J.Y., Boreham, D.R., and Somers, C.M 2017. Isotopic structure of Lake Whitefish in Lake Huron: evidence for regional and local populations based on resource use. North American Journal of Fisheries Management 37:133-148.


Eberts, R.L., Wissel, B., Manzon, R.G., Wilson, J.Y., Boreham, D.R., and Somers, C.M. 2016. Consistent differential resource use by sympatric Lake (Coregonus clupeaformis) and Round  (Prosopium cylindraceum) Whitefish in Lake Huron: a multi-time scale isotopic niche analysis. Canadian Journal of Fisheries and Aquatic Sciences73:1072-1080.

Thome, C., Mitz, C.,Somers, C.M.,Manzon, R.G.,Boreham, D.R., Wilson, J.Y..2016. Incubation of Lake Whitefish (Coregonus clupeaformis) embryos in cooling water discharge and the impacts of fluctuating thermal regimes on development. Canadian Journal of Fisheries and Aquatic Sciences73:1213-1221.

 D, Hutchinson S, Collymore C, Bruce A.E.,Louis R, Ghalami A, Allison W.T., Ekker M, Eames, B.F., Childs, S, Kurrasch, D.M., Gerlai, R, Thiele, T, Scott I, Ciruna, B, Dowling J, McFarlane S, Huang P, Wen X, Drapeau P, Babiuk L.A., Dragon D., Smida A, Buret A.G., O’Grady E., Wilson J, Sowden-Plunkett L,and Tropepe , V.  2016. Restrictions on the importation of zebrafish into Canada associated with spring viremia of carp virus. Zebrafish 13 Suppl 1:S153-163.

Lee, A.H., Eme, J., Mueller,C.A.,Manzon, R.G., Somers, C.M., Boreham,D.R., Wilson, J.Y.. 2016. The effects of increased constant incubation temperature and cumulative acute heat shock exposures on morphology and survival of Lake Whitefish (Coregonus clupeaformis) embryos. Journal of Thermal Biology 57:11-20.

Graham CF, Eberts RL, Morgan TD, Boreham DR, Lance SL, Manzon RG, Martino, J.A., Rogers, S.M., Wilson, JY.,and Somers, C.M. 2016 Fine-Scale Ecological and Genetic Population Structure of Two Whitefish (Coregoninae) Species in the Vicinity of Industrial Thermal Emissions. PLoS ONE11(1): e0146656.

Stefanovic, D.I., Manzon, L.A., Boreham, D.R., Somers, C.M., Wilson, J.Y., Manzon, R.G. 2016. Thermal Stress and the Heat Shock Response in Embryonic and Young of the Year Juvenile Lake Whitefish. Comparative Biochemistry and Physiology A, 193:1-10.


Graham, C., Glenn,T.C., McArthur, A., Boreham, D.R., Kieran, T., Lance, S. Manzon, R., Martino, J.A., Pierson, T.,Rogers, S.M., Wilson, J. and Somers, C.M. 2015. Impacts of degraded DNA on Restriction Enzyme Associated DNA Sequencing (RADSeq). Molecular Ecology Resources, 15:1304-1315.

Sreetharan, S., Thome, C., Mitz, C. Eme, J., Meuller, C, Hulley, E., Manzon, R.G., Somers, C.M., Boreham, D., and Wilson, J.Y. 2015. Embryonic development of lake whitefish (Coregonus clupeaformis): a staging series, analysis of growth and impacts of fixation. Journal of Fish Biology 87:539-558.

Mueller, C.A., Eme, J., Boreham, D., Manzon, R.G., Somers, C.M., and Wilson, J.Y. 2015. Embryonic Critical Windows: Changes in incubation temperature alter survival, hatchling phenotype, and cost of development in Lake whitefish (Coregonus clupeaformis) embryos. Journal of Comparative Physiology B, 185:315-331.

Eme, J., Mueller, C.A., Manzon, R., Somers, C.M., Boreham, D.R. and Wilson, J.Y. 2015.Critical windows in embryonic development: Shifting incubation temeraptures alter heart rate and oxygen consumption of Lake Whitefish (Coreogonus clupeaformis) embryos and hatchlings. Comparative Biochemstry and Phsyiology Part A Molecular and Integrative Physiology 179:71-80.


Dejong, C. and Wilson, J.Y 2014. The cytochrome P450 superfamily complement (CYPome) in the annelid Capitella telata. PlosONE, 9:e107728.

Shaya, L, Dejong, C, and Wilson, J.Y. 2014.Expression patterns of cytochrome P450 3B and 3C genes in model fish species. Comparative Biochemistry and Physiology Part C Toxicology and Pharmacology 165:115-125.

Mitz, C, Thome, C, Cybulski, ME, LaFramboise, L, Wilson, JY1 and Boreham, D1. 2014. Small-scale rearing of Lake Whitefish (Coreogoneus clupeaformis) embryos for experimental aquaculture. North American Journal of Aquaculture 76:179-184. 1 equal contributors

Galus, M, Rangaranjan, S., Lai, A., Shaya, L., Balshine,S. and Wilson, J.Y. 2014. Effects of chronic, parental pharmaceutical exposure on zebrafish (Danio rerio) offspring. Aquatic Toxicology, 151:124-134.


Galus, M., Kirischian, N., Higgins, S., Purdy, J., Chow, J., Ragaranjan, S., Li, H., Metcalfe, C., and Wilson, J.Y. 2013. Chronic, low concentration exposure to pharmaceuticals impacts mulitple organ systems in zebrafish. Aquatic Toxicology,132-133:200-211 .

Galus, M., Jeyaranjaan, J., Smith, E.M., Li, H, Metcalfe, C., and Wilson, J.Y. 2013. Chronic Effects of Exposure to a Pharmaceutical Mixture and Municipal Wastewater in Zebrafish. Aquatic Toxicology, 132-133:212-222.


Smith, E.S., Iftikar, F.I., Higgins, S., Irshad, S., Jandoc, R., Lee, M., and Wilson, J.Y. 2012. In vitro inhibition of cytorchrome P450-mediated reactions by gemfibrozil, erythromycin, ciprofloxacin and fluoxetine in fish liver microsomes. Aquatic Toxicology, 109:259-266.


Harskamp, J., Britz-McKibbin, P., and Wilson, J.Y. 2011. Functional Screening of Cytochrome P450 Activity and Uncoupling by Capillary Electrophoresis. Analytical Chemistry, 84: 862–866.

Kirischian, N.L. and Wilson, J.Y. 2011. Phylogenetic and functional analyses of the cytochrome P450 family 4. Molecular Phylogenetics and Evolution, 62:458-471.

Kirischian, N., McArthur A.G., Jesuthasan C., Krattenmacher B., and Wilson J.Y. 2011. Phylogenetic and Functional Analysis of the Vertebrate Cytochrome P450 2 Family. Journal of Molecular Evolution, 72:56-71.


Scornaienchi, M.L., Thornton, C., Willett, K.L., Wilson, J.Y.  2010. Cytochrome P450 mediated 17-beta estradiol metabolism in zebrafish (Danio rerio). Journal of Endocrinology, 206:317-325.

Marentette, J.R., Gooderham,K.L., Hynes, H., McMaster, M.E.,  Ng, T., Parrott, J.L., Slater, G.F., Wilson, J.Y., Wood, C.M., and Balshine, S. 2010. Signatures of Contamination in Invasive Round Gobies (Neogobius melanostomus): A double strike for ecosystem health in highly polluted areas? Journal of Ecotoxicology and Environmental Safety, 73:1755-1764.

Scornaienchi, M.L., Thornton, C., Willett, K.L., Wilson, J.Y.  2010. Functional differences in the cytochrome P450 1 family enzymes from Zebrafish (Danio rerio) using heterologously expressed proteins.  Archive of Biochemistry and Biophysics, 502:17-22.

Bowley, L.A., Alam, F., Marentette, J.R., Balshine, S., Wilson, J.Y. 2010. Characterization of vitellogenin gene expression in round goby (Neogobius melanostomus) using a quantitative PCR assay. Environmental Toxicology and Chemistry, 29:2751-2760.

Smith, E.M. and Wilson, J.Y. 2010. Assessment of cytochrome P450 fluorometric substrates with rainbow trout and killifish exposed to dexamethasone, pregnenolone-16α-carbonitrile, rifampicin, and β-naphthoflavone. Aquatic Toxicology 97:324-333.

Smith, E.M., Chu, S., Paterson, G., Metcalfe, C.D. and Wilson J.Y. 2010. Cross species comparison of fluoxetine metabolism with fish liver microsomes. Chemosphere 79:26-32.

Wilson, J.Y. and Stegeman J.J. 2010. Catalytic and Immunochemical Detection of Hepatic and Extrahepatic Microsomal Cytochrome P450 1A1 (CYP1A1) in White-sided Dolphin (Lagenorhynchus acutus) Aquatic Toxicology 96:216-224.


Noori, A., Selvaganapathy, P.R., and Wilson, J. 2009. Microinjection in a microfluidic format using flexible and compliant channels and electroosmotic dosage control. Lab on a Chip 9: 3202:3211.


Hooker, S.K., Metcalfe, T.L., Metcalfe, C.D., Angell, C.M., Wilson, J.Y., Moore, M.J., and Whitehead, H. 2008. Changes in persistent contaminant load and CYP1A1 enzyme activity in biopsy samples from Northern bottlenose whales, Hyperoodon ampullatus, following the onset of nearby oil and gas activity. Environmental Pollution, 152 (1): 205-216.


Wilson, J.Y., Wells, R. Aguiliar, A., Borrell, A., Tornero, V., Reijnders, P., Moore, M., and Stegeman, J.J.  2007. Corrrelates of cytochrome P450 1A1(CYP1A1) expression in bottlenose dolphin (Tursiops truncatus) integument biopsies. Toxicological Sciences, 97(1):111-119.


Garrick, R.A., Woodin, B.R., Wilson, J.Y., Middlebrooks, B.L., and Stegeman, J.J.  2006.  Cytochrome P4501A is induced in endothelial cell lines from the kidney and lung of the bottlenose dolphin, Tursiops truncatus. Aquatic Toxicology, 76(3-4):295-305.


Wilson, J.Y., Cooke,S.R., Moore, M.J., Martineau, D., Mikaelian, I., Metner, D.A., Lockhart, W.L., and Stegeman, J.J. 2005.   Systemic Effects of Arctic Pollutants in Beluga whales Indicated by CYP1A1 expression.  Environmental Health Perspectives, 113(11):1594-1599.

Wilson, J.Y., McArthur, A.G., and Stegeman, J.J. 2005. Characterization of a Cetacean Aromatase (CYP19) and the Phylogeny and Functional Conservation of Vertebrate Aromatase.  General and Comparative Endocrinology, 140:74-83.


Angell, C.M., Wilson, J.Y., Moore, M.J. and Stegeman, J.J. 2004 Cytochrome P450 1A1 expression in cetacean integument: implications for detecting contaminant exposure and effects.  Marine Mammal Science 20(3):554-566.

Godard, C., Smolowitz, R., Wilson, J.Y., Payne, R., Stegeman, J.J. 2004. Induction of cetacean cytochrome P4501A1 by B-naphthoflavone exposure of skin biopsy slices. Toxicological Sciences 80:268-275.


Wilson, JY; Kruzynski, GM; Addison, RF. 2001. Experimental exposure of juvenile chinook (Oncorhynchus tshawytscha) to bleached kraft mill effluent: hepatic CYP1A induction is correlated with DNA adducts but not with organochlorine residues. Aquatic Toxicology, 53(1):49-63.


Wilson, J.Y., Addison, R.F., Martens, D., Gordon, R. and Glickman, B. 2000. Cytochrome P450 1A and related measurements in juvenile chinook (Oncorhynchus tshawytscha) from the Fraser River.  Canadian Journal of Fisheries and Aquatic Sciences,  57(2):405-413.


Hodson, P.V., Efler, S., Wilson, J.Y., El-Shaarawi, A., Maj, M. and Williams, T.G. 1996. Measuring the Potency of Pulp Mill Effluents for Induction of Hepatic Mixed Function Oxygenase Activity in Fish. Journal of Toxicology and Environmental Health, 49(1):83:110.


LaPierre, N., Wilson, J., Bourreau, J.P., Tougas, G., Kwan, C.Y., Daniel, E.E. 1993. Norepinephrine Release in Rat Vas Deferens – Effect of Rauwolscine and BHT-920. Life Sciences, 53(2): PL19-PL24.

Recent Posts

Recruitment begins

I’m not sure I can adequately describe the size or scale of the impact in our lab over the last year+ but this pandemic was dishing things out left, right and centre.  I feel like we are at a nexus of where the pandemic really delayed and harmed our research program.  The personal impacts for many in my group have likewise been large and the largest goal was to try to keep all of us upright, in science, and keeping our heads above the water.  In that regard, we need to reassess and redefine success over the last year.  We have survived (!!) and this was largely from the resilience of our group, as much as I think that is an overused term.  But we did get through this year together, pivoting efforts, helping each other, focusing on what we could do, taking things one step at a time.  Now we are starting to see progress in projects again and productivity is starting to leap back up.  That provides some space to look forward and plan for the future.  Let’s start with some lab success stories.  I’ll add in where we will be recruiting in the upcoming year in these projects.  A detailed outline of our open positions in 2021-2022 will be posted, so please check them out and get in touch if you are interested in our research program.

When the pandemic shut down McMaster, yellow perch were spawning and we were about to launch into working with a brand new species.  Waiting a full 12 months to restart was very hard but spring 2021 saw us undertaking the experiments we canceled the year before (and then some!) with very good outcomes.  The lab (especially Shamaila Fraz) came roaring back with ambitious plans that were very fruitful and lots of experiences in testing new protocols to help move research plans forward.  I am quite excited to see the data collection from our new samples and the analyses from the data already collected.  It will shape the direction of our research into developmental plasticity and impacts of temperature on fish development.  Much of our work this year focused on embryogenesis and immediate post-hatching periods while we work on the juvenile rearing stages. Perch are definitely a bit tough to rear post-hatching, compared to the other species we have worked on.  No surprise but we certainly learned some things not to do to keep them happy.  We are looking to recruit for this project in the upcoming months so we are ready to take on spring 2022 spawn.

While we graduated two graduate students from the lab in 2021, clear success stories, these were students who were done data collection prior to university shut down.  Other graduate students in the lab faced much bigger challenges. With major lost experiments and one totally new project later, we forged a new plan to get back on track. I’m really excited about these new directions.  Andrea Murillo has a freezer full of samples taken from our culture of the marine polychaete worm, Capitella teleta, and she is now extracting those samples to get geared up for gene expression and steroid hormone analyses.  Shemar Williams has completed a suite of experiments in zebrafish embryos and on track to finish his MSc.  Its great to see these project humming along.  This also means it is time to think about new graduate students in 2022 interested in the function of cytochrome P450 enzymes using either zebrafish or Capitella as a primary species of interest.

Success, of course, has also been obvious in more traditional ways. We have been so happy to celebrate Oana Birceanu’s success this year as she starts her new role at Western’s Physiology and Pharmacology department as an Assistant Professor. I look forward to continued collaboration and engagement with her research group in the years to come.

**  If you are interested in our lab, please check back under “Recruitment Opportunities” for more details in the upcoming days. I will be posting specific information there.  The much needed refresh of the lab website is just beginning.


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