Our Research

Cytochrome P450 Enzymes and Aquatic Toxicology

My research focuses on cytochrome P450 enzymes and the effects of environmental contaminants on aquatic species.  My research intersects environmental physiology, biochemical toxicology, and bioinformatics and functional genomics

Environmental Physiology:

We are interested in the physiological impacts of contaminants, particularly human pharmaceuticals, on aquatic species.

Biochemical Toxicology:

We study the evolution and function of cytochrome P450 enzymes, a protein superfamily that is important for production and metabolism of steroid hormones, and critical for drug metabolism.

Bioinformatics and Functional Genomics:

We are involved in annotation of cytochrome P450 genes in fish genomes, bioinformatics approaches in support of our evolutionary studies, and transcriptomics (using microarrays) to examine how contaminants alter gene expression in fish.

Recent Posts

Bring on the summer!

With each academic term change, there can be a change in who is doing research in the Wilson Tox Lab.  But summer and fall term mark times of large change, as undergraduates  and graduate students complete their thesis research, write up, and move on to new challenges.  This year it is a bit of an exception as many of the undergraduates that have been working in our lab over the last year are staying to continue their research.  Kirill Pankov, an undergraduate student that works between Dr. Andrew McArthur’s lab and Wilson Tox Lab, had a very successful thesis.  He won the best thesis presentation for the Biomedical Discovery and Commercialization Program (BDC); no mean feat considering he was discussing his research in Cnidarian genomes!  Kirill is continuing to work on that project over the summer with the hopes that we are wrapping up a project spanning multiple Cnidarian genomes and will be able to move into nomenclature of the cytochrome P450 genes in this important animal phylum.  Caitlin West and Devon Jones completed their undergraduate theses in the Biology, Physiology Specialization Program and are remaining in the lab to contribute to our whitefish program (Caitlin) and mouse fetal programming project (Devon).  Devon won best poster presentation for the Biology Department’s senior thesis class.  Caitlin has just won the best video in the iClimate video competition, showcasing excellent science communication skills.  Check out her video on the iClimate Facebook page; a link is provided on our research pages.  These are just three of the seven undergraduates working in the lab this summer.

We do have a few new people that have joined the lab in 2017.  Meghan Fuzzen joined us in January to begin a post doctoral fellowship after completing her PhD at Waterloo.  She was actually out in the field with us in late fall for whitefish spawning, working ahead of her PDF to get experiments going.  Hard core scientist in our midst and we are so glad to have her!  Allison Kennedy is another post doctoral fellow that has joined the group more recently.  Allison has been working at NOSM with our collaborator, Dr. Doug Boreham, and has moved to McMaster to work on our Mouse Fetal Programming project as part of our ongoing collaboration with the Boreham lab.  We also have two new PhD students in our midst this summer.  Andrea Murillo has moved from the University of Regina and Dr. Richard Manzon’s lab to complete her PhD with us.  We have gotten to know Andrea over the last two years of her MSc degree, where she worked on heat shock proteins in developing whitefish.  We were lucky enough to have her in the field with us each fall for the last few years, collecting spawning whitefish to perform IVF and generate embryos for our research program.  Andrea’s research is going to move us into more invertebrate species and allow us to continue our research on cytochrome P450 enzymes in the marine annelid worm, Capitella telata.  James McEvoy will be joining us shortly from Australia, where he is completing a PhD at Flinders University.  He is our first Cotutelle student and will get his degree from both Flinders and McMaster!

And of course, we are starting to look forward to fall and the next major change in the lab.  Three graduate students are wrapping up their research; both Adam and Shayen will be finishing their MSc degrees by fall term and Shamaila is finishing the last bit of her PhD research this summer.  So between research and writing manuscripts, this is shaping up to be one exciting summer in the Wilson Tox Lab.

  1. Meet Devon Jones, undergraduate researcher Leave a reply
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